Progesterone not effective in serious brain injury
A severe traumatic brain injury (TBI) needs immediate treatment. For long researchers have being trying to find out the exact way to treat such patients. In the latest move some researchers used progesterone to see its impact.
The result was not forthcoming as it showed no improvement in clinical outcome. This has been confirmed by a new study published online in The New England Journal of Medicine on December 9.
Raj K. Narayan, MD, executive director, North Shore-LIJ’s Cushing Neuroscience Institute and one of the co-authors of the paper, said: “This trial, referred to as SYNAPSE, reports on a large prospective randomized clinical trial that investigated the effects of progesterone administered to severe TBI patients. Despite extensive experimental support in numerous animal models, as well as very promising preliminary data from smaller single centre trials, this Phase III study failed to show benefit of progesterone in severe TBI.”
The findings of the study were published after going through 1,195 patients from across the world. Most of them were put into randomized placebo-controlled trial, between 16-70 years of age. And those who were selected for the trial had severe TBI and they were given progesterone or placebo. The results were not effective.
Shortlink:
0 comments:
Post a Comment